Genomics	Proteomics	Multiplexed Arrays

Introducing the NovaRay® Detection Platform – the next-generation imaging solution for arrays in microplates from Alpha Innotech Corporation.
The new system offers for dye versatility and multi-substrate compatibility (ability to also work with slides and novel substrates).The NovaRay Detection Platform provides unparalleled flexibility for microarray applications in functional genomics, proteomics, cellomics, gene expression and drug discovery research. A state-of-the-art design, complemented by an optimized hardware-software configuration. ensures superior image quality, linear dynamic range, reproducibility and data integrity for high throughput imaging needs. Your search for an imaging system to address novel microarray applications in the post-genomic era ends here!

Features:
• High Image Resolution
• Sample Format Versatility• High Sensitivity
• Well-centric Scanning• User-optimized Fluorescent Dye Flexibility
• OEM Analysis Software available


Product Overview

High Image Resolution

The NovaRay scanner provides:
• High quality, dual-channel imaging down to 4 micron resolution.
• User-optimized scanning protocol enables selection from 4 resolution settings of 4, 5, 10 and 20 microns.
• Ability to perform cell based reporter assays, viral plaque assays and cell arrays.
• Ability to QC substrates.
• Ability to scan plates at high resolution opens a world of opportunity in studying proteins and gene expression in cells.
• User-control over the scanning area and acquisition time for sub-image scans. This ensures a more convenient process for the user to take a series of scans and enables closer investigation of specific sub-image features.

High Sensitivity
The NovaRay scanner utilizes a proprietary light management design that enables the system to acquire high quality images. This results in:
• Ability to study low-expressed genes.
• Minimal photo-bleaching that enables for accurate repeat measurements.
• High integrity of ratio-metric intensity data.



                  [Scan Image of Full Moon Bio Slide]



User-optimized Fluorescent Dye Flexibility
The NovaRay scanner utilizes separate filter wheels, each with up to 8 filters, for both excitation and emission wavelengths.
• Optimized with standard filter sets for Cy3 and Cy5 dyes that minimizes bleed-through and crosstalk between these common dyes.
• Cost-efficient evaluation of new fluorescent molecule choices, enabling adoption of less expensive and more stable dyes.
• Multi-channel scanning of up to eight different dyes in one experiment allows for development of novel multiplexed assays.
• Application convergence on a single scanner can be achieved with the right choices in filter selection. The NovaRay scanner can accomplish this because it is compatible across the range of UV, visible light, and NIR dyes. This reduces the need for researchers to add new laser excitation sources or reconfigure their instrument between experiments.
• As with excitation, the eight-position emission filter wheel of the NovaRay scanner enables researchers to select from hundreds of dye choices with optimized emission filters. For ordering information on alternative emission filters, please contact Alpha Innotech.

DiD (Cy5)
DiI (Cy3)
Nile Red (Cy3)
Hoechst(Coumarin)
Image Courtesy of Integral Molecular






Sample Format Versatility
• Microplate scanning capability allows for quick and cost effective screening of many samples, resulting in increased throughput and data accuracy when using automated fluid handlers.



• Designed to handle single slide acquisitions as well as a batch of up to 4 microscope slides.

• Able to accept wet or dry samples, including tissue samples (see Application Note).

• Speeds up research process through usage of high throughput assays such as array-of-arrays and high-throughput screening.

• Enables development of novel assay platforms with non-standard substrates.









Well-centric scanning
• Fast scan times
• Ability to mask unwanted inter-well regions
• Enables single-cell detection
• Able to scan live cells (in media) allows for time course studies

“Alpha Innotech is not licensed under any patents owned by Oxford Gene Technology Limited (“OGT”), covering oligonucleotide arrays and methods of using them to analyze polynucleotides. The purchase of Alpha Innotech’s products does not convey any license under any of OGT’s patent rights, including any right to make or use oligonucleotides under OGT’s patents.

“Customers may use Alpha Innotech’s products to analyze oligonucleotide arrays according to OGT’s patented methods if those arrays have either been purchased from OGT’s licensed suppliers, or have been made by the customer under a license from OGT.
Please contact OGT to enquire about a license under OGT’s patents at licensing@ogt.co.uk”